[Grizzly]

STALKER: Call of Pripypat: when I ventured into lab X8
the main emotion was that of fear.
what is this place?
WHAT THE **** SEES ME!??!
WHY AM I TAKING DAMAGE
auto-shotgun owns snorgs, hehehe
what is that sound?
a child weeping?
must be a trap, but...
...****ING BURER!
**** it, I have a document, I'm out of here

Yeah, STALKER has the tendency to either scare you or give you the chills when people take science a bit too far...

[T-LoW]

Knights of the old Republic - the biggest plot-twist in video game history...

[Roanoke]

....were it not for System Shock 2!

[NGTM-1R]

Knights of the old Republic - the biggest plot-twist in video game history...

....were it not for System Shock 2!

Were it not for Deus Ex.

[Nuclear1]

Chalk another up there...
Heavy Rain.  If you've played it, you know EXACTLY what scene I'm talking about.

[General Battuta]

Chalk another up there...
Heavy Rain.  If you've played it, you know EXACTLY what scene I'm talking about.

JASON!?

JASON!

PRESS X TO JASON

[Nuclear1]

Chalk another up there...
Heavy Rain.  If you've played it, you know EXACTLY what scene I'm talking about.

JASON!?

JASON!

PRESS X TO JASON

Not that particular scene

Square + L1+ R1 + (Shake controller down)

[Deepstar]

The Outtro of Prince of Persia - The Sands of Time

"What, another Sathanas?" in FreeSpace2
The awake of the Nyarlathotep in FreeSpace2:Derelict

The death of "spirit" in Wing Commander II: Vengeace of the Kilrathi
The death of "minx" in Wing Commander II: Special Operations 2
The death of "angel" in Wing Commander III: Heart of the Tiger
Wing Commander IV: Price of Freedom in a whole

The "treason" of Arthas in WarCraft III and that he kills his former friends

the return of Jade to the Lighthouse in Beyond Good and Evil



The complete game ICO
The complete game Shadow of the Colossus

The complete game Archimedean dynasty
the death of Admiral Cox in AquaNox
the death of Lisa Bonham in AquaNox
the death of Amitab in AquaNox2:Revelation
the "death" and return of Angelina in AquaNox2:Revelation

more to follow...

[mxlm]

Were it not for Deus Ex.

What a shame.

[Mongoose]

the return of Jade to the Lighthouse in Beyond Good and Evil

The complete game ICO
The complete game Shadow of the Colossus

Yus, yus, and yus.

[Triple Ace]

Blue Planet: AoA

Spoiler:

Sam reliving the mission in Capella where his wife and mother were killed.

Fallout 3

Spoiler:

Watching your father's death at Project Purity and then your own at the end. Although, you live if you have Broken Steel installed.

Resident Evil 5

Spoiler:

Chris and Jill reuniting after the fight.

The Sabotuer

Spoiler:

When Sean watches his best friend get tortured and murdered by the Nazis.

Half-Life 2 Episode 2

Spoiler:

Seeing Alyx nearly die after getting impaled by the hunter, and seeing Eli die at the end when his brain gets sucked by the advisor.

Bioshock 2
All three endings got to me.

Spoiler:

The good ending when Elenor absorbs Delta's memories to save him and so he can guide her. The nuetral ending where Delta chooses to die so Elenor can be redeemed for for the evil she has done before their escape. And the Evil ending where Elenor takes Delta's memories to gain his killer and survival instincts to use against the world.

Sam & Max 305: The City That Dares Not Sleep

Spoiler:

Max's death, followed by Sam's sad walk through the city during the credits, where his head is lowered as he bypasses all of the crimes in progress. The piano music playing in this scene was beautiful and helped set the mood. Then there was the twist that came afterwards.

[BloodEagle]

Fallout 3

Spoiler:

Watching your father's death at Project Purity and then your own at the end. Although, you live if you have Broken Steel installed.

....  I most emphatically disagree with the notion that either of those two events were either emotional or 'impactful'.  Most emphatically.

[Triple Ace]

If it wasn't, at least it was an attempt to be.

[Colonol Dekker]

Any game of minesweeper that ends with two or three unchecked tiles. Especially a HUGE game.
 
It fills me with Raaaaaaaaaaaage-uh.

[Mongoose]

Oh God yes.  You know you're going to always pick the wrong one, no matter what the odds are.

[Deadly in a Shadow]

Totally impactful was the moment when I heard that there are far more than one Sathanas-Juggernauts in the Nebula

And F.E.A.R (+ expansions), full of impactful moments if you understand
 

[Akalabeth Angel]

PoP - Sands of Time - the last bit of end cinematic when the Prince tells her his name
Thief - going into the haunted Cathedral or exploring the lost city were both pretty intense. I'd get goosebumps just fighting this friggin little spiders because health and arrows were precious and it was hard to hit with the sword.

[Colonol Dekker]

Lone Wolf suprisingly got to me in Reach even though I've known Reach falls since 2001.

[Scotty]

I liked Lone Wolf as purely a display of the sheer ballsy badassitude of Noble 6.

And yeah, it got to me a bit.

[General Battuta]

I liked Lone Wolf mostly as a way of (finally) integrating gameplay and story the way Halo has so often failed to.

Unfortunately they chickened out and didn't let you play the actual death, just went to a cutscene. Then they wrecked it with the awful Halsey monologue.