It's perfectly possible to make a jump and run game work well with keyboard+mouse. However, the control layout, gameplay, and level layout would be significantly different then a console jump and run, for the sake of taking advantage of the PC's strengths rather then a console's strengths. An excellent PC port should include control changes to make the game work better with mouse+keyboard, and possibly some small level tweaks to accommodate the different capabilities the PC control setup has.
But there is a very good reason why fighting games are much more common on consoles then on the PC. That sort of game is meant for a gamepad, which PC owners aren't guaranteed to have. Those types of games also usually support local multiplayer, which sadly is not a standard feature on PC games. The fighting game is very much a genre meant for consoles and arcades.