ROCK ON.
I play two factions: The Step-Daughters of Gaia (Worm World Domination!) or the Human Hive.
With Deidre and the Step-Daughters, I have only one goal: total domination through the complete and utter master of Planet and its Worms. Early in the game no one can stand up to the might of Mindworms, and as the game goes on, you capture Demon Boil Locusts of Chiron. By that time, you should have every Secret Project, and should be able to take over as the global president. No one can stand against you. My enemies end up feeding the trees.
As the Hive, I play hard core tech dominance. I get antigrav or the space elevator and put drop pods on shock troopers, some defensive units and colony pods, and I start lobbing bases all over Planet, usually right next to enemy cities. I then proceed to annihilate or subvert everything from within. For home defense, I generally keep a good balance of mindworm variants and heavy defensive units, along with a few heavy drop troops.
I get so caught up when playing--especially as the Hive--that I start imagining the plots and intrigues and stuff that goes on behind the scenes. I always imagine that Chairman Yang isn't out to to conquer the world so much as he's out to absorb it, become one with it and become the guiding imagination behind a vast multi-body organism.

I love that game.