voice can be a little complicated in targeting if you have multiple enemies. they aren't listed by a number or name.
A single enemy in a mission is easy but for multiple you should target it (y)
When I got a certain one (a Lilith) in my reticle I haven't targeted yet:
"Target (y)", "Comm (c)", "all"l (all fighters), "Kill"(Destroy my target)... IIRC
Things in missions change so for some things you DON'T want all in one commands.
All-in-ones should basicly be for something you actively have targeted already, from the ship/command list so it's pretty straightforward. (though I never tried those).