I've recently pulled down the new media vps and reinstalled FS2 to have a bash with the new builds, and everything's looking great! However, I had several crashes when accidentally locking onto debris with 'target ship in reticle'. I restarted in a debug buid to get a spew, and I find that the 'target ship in reticle' behaviour is different, and that it's much harder to 'accidentally' get a worthless piece of debris if there's an actual target in that direction. With the release build, I pointed straight at a science ship in Fall of Epsilon Pegasi, and locked onto a debris piece BEHIND it and crashed.
So I can't replicate it with the debug build, although it's very common in the release build. I'm using Karajormas 17-5-06. Is this a known problem? It's all fresh - I've reinstalled FS2, patched, thrown the launcher and a build in with the new media vps.