[Ace]

Scientists have proved for the first time that sperm grown from embryonic stem cells can be used to produce offspring.

The discovery in mice could ultimately help couples affected by male fertility problems to conceive.

And by understanding embryo developmental processes better, a host of other diseases might be treated using stem cells, they say.

The study is published in the journal Developmental Cell.

Growing sperm

The experiment was carried out using mice and produced seven babies, six of which lived to adulthood.

However, the mice showed abnormal patterns of growth, and other problems, such as difficulty breathing.

As well as the safety concerns, using stem cells from embryos to create sperm also raises ethical questions.

   
For the first time we have created life using artificial sperm
Professor Karim Nayernia

Q&A: Stem cells

Stem cells are special because they have the potential to develop into any tissue in the body.

Professor Karim Nayernia and colleagues at the Georg-August University in Göttingen, Germany, took stem cells from a mouse embryo that was only a few days old and grew these cells in the laboratory.

Using a specialised sorting instrument they were able to isolate some stem cells that had begun to develop as sperm.

They encouraged these early-stage sperm cells, known as spermatogonial stem cells, to grow into adult sperm cells and then injected some of these into female mouse eggs.

The fertilised eggs grew and were successfully transplanted into female mice and produced seven babies.

Professor Nayernia, who now works at Newcastle University in the UK, said: "For the first time we have created life using artificial sperm. This will help us to understand how men produce sperm and why some men are unable to do this.

Restoring fertility

"If we understand this we can treat infertility in men."

In the future, men with fertility problems might be able to have their own stem cells harvested using a simple testicular biopsy, matured in the lab and then transplanted back.

It is estimated that one in seven UK couples have difficulty conceiving - about 3.5 million people. In about a third of all couples having IVF, male fertility is a contributory factor.

   
It is more difficult to say whether artificial sperm produced this way could ultimately be used as a new treatment for male infertility
Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield

About 1% of all men don't produce sperm and a further 3-4% of men have a low sperm count that could lead to infertility.

Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield and honorary secretary of the British Fertility Society, said: "To be able to make functional sperm under controlled conditions in the laboratory will be very useful to study the basic biology of sperm production.

"There are currently many things we don't know about how sperm are formed let alone why it sometimes goes wrong and leads to infertility in some men."

But he added: "It is more difficult to say whether artificial sperm produced this way could ultimately be used as a new treatment for male infertility. There are many technical, ethical and safety issues to be confronted before this could even be considered."

Ethical and safety issues

Professor Harry Moore, professor of reproductive biology at the University of Sheffield, said: "These processes in the test-tube are far from perfect as the mice that were born by this process were abnormal.

"We therefore have to be very cautious about using such techniques in therapies to treat men or women who are infertile due to a lack of germ stem cells until all safety aspects are resolved. This may take many years."

Anna Smajdor, a researcher in medical ethics at Imperial College London, said: "The creation of viable sperm outside the body is a hugely significant breakthrough and offers great potential for stem cell research and fertility treatments.

"However, sperm and eggs play a unique role in our understanding of kinship and parenthood, and being able to create these cells in the laboratory will pose a serious conceptual challenge for our society."

Josephine Quintavalle, of Comment on Reproductive Ethics, agreed.

She said the use of adult stem cells from sources such as umbilical cord blood had consistently produced more promising results than the use of embryonic stem cells.

Professor John Burn, professor of clinical genetics at Newcastle University, believes stem cells will be a treatment for all types of diseases.

"The same approach could ultimately allow us to control the development of liver cells, heart cells or brain cells... and make treatments for virtually any tissue that is damaged or diseased."

http://news.bbc.co.uk/2/hi/health/5166462.stm

Well not really, but an interesting development.

[Flipside]

Interesting stuff, though, they themselves admit, the technique isn't perfect yet. Still, it all adds to knowledge so that maybe in the future we can deal with those problems

[karajorma]

They say we're obsolete now but in 5 years they'd all be sitting in the dark wondering how to make fire

Seriously though it's very interesting

[NGTM-1R]

There goes the neighborhood...

[neoterran]

They say we're obsolete now but in 5 years they'd all be sitting in the dark wondering how to make fire

Seriously though it's very interesting

Well, that was a particularly sexist comment. I expected as much from you, Karajorma.

[Flipside]

Either you are continuing the joke or you didn't see the 'sticking out tongue' smiley at the end of his comment.... I'm still trying to figure out which.

[Rictor]

Why do people feel the necessity to screw with a good thing?

Stupid, stupid, stupid people.

[Flipside]

Because there is this attitude that if we can do a thing, we therefore must do it. It's one of the real dangers of science to be honest, which is why it needs to be applied with Ethics, otherwise Designer Children and Eugenics are just the start of a problem that we will be reaping in generations to come, simply because we don't fully understand what we are doing. In some ways, we can't learn until we try, but I don't feel playing games with the Gene Pool with cloning and things is far from the best course to take by a long shot.

[Grug]

It still needs an initial embryo as I understand it anywho. But yah, interesting stuff.
Almost getting to the point where a woman can become an asexual reproducer. Scary stuff. =o

[Sandwich]

Why do people feel the necessity to screw with a good thing?

I'm normally not the one for such comments, but in light of this thread topic, that statement is particularly amusing.

[Mefustae]

[neoterran]

 

 : I was continuing the joke, of course. my deadpan delivery didn't translate well without the use of this smiley : 

[Descenterace]

Thing is, we've been playing with the gene pool of other species ever since we started farming, and our own gene pool ever since society started protecting people from their stupid actions. Personally, I reckon we're too far gone anyway.

[achtung]

Isn't the Y chromosome supposed to turn out going extinct in about 10-15 thousand years?

[Fragrag]

Isn't the Y chromosome supposed to turn out going extinct in about 10-15 thousand years?

Pff, I wouldn't even get laid by then.

[aldo_14]

Isn't the Y chromosome supposed to turn out going extinct in about 10-15 thousand years?

Pff, I wouldn't even get laid by then.

Juxtaposed nicely with "On this day...my pants are filled....with joy", I note.