Wheel of Time absolutely rocks--as an audiobook. It flows better, surprisingly.
The Sword of Truth is awesome, in my opinion. Fair warning though: the whole series is a fantasy interpretation of Ayn Rand's objectivist philosophy.
Jacqueline Carey's Kushiel novels are masterful, if you can get past the central character being a sexual masochist and you don't mind Christianity being mucked about with. These books appealed to me on many levels, not the least the idea of Christ's blood and the earth mixing to produce a new, more wordly god.
George R. R. Martin's A Song of Ice and Fire is as good as you'll ever get in the realm of modern epic fantasy. It is at once subtle in detail and audacious on scope. I've never been rivetted so thoroughly by a fantasy series. Its a reimagined medieval Europe on the edge of winter that will last decades. There's not much magic, but what's there is inspiring.
Susan R. Matthews Bench series. Scifi stories set in a stellar nation ruled by Law, devoid of moral guidance. Cautionary and chilling at times and less about the technology than horrible things nations do to individuals in the name of Justice. Fair warning: the main character for most of the books is a self-loathing sadist, and Matthews style is rather raw at times. The end result is, in my opinion, utterly beautiful.
Any C. S. Friedman, especially the Coldfire Trilogy. Fantasy (nominally scifi due to background) about a world where human thoughts uncontrollably affect the environment around them, causing magical effects and manifesting people's fears. Features the best priest ever and one of the best fallen men I've ever read. Absolutely excellent. Also of note is the Madness Season (a science fiction take on a vampire and an alien invasion) and This Alien Shore (a story about the many uses of human mental diseases).
Stephen Donaldson's Gap series is worth reading if you don't mind a story in which every main character is designed to be loathsome. Fair warning, Donaldson seems to have a fetish for having leading men rape leading women. Its happened at least once in every series I've read by the man.
Carol Berg's Books of the Rai-kirah are fun fantasy about a slave and the prince who owns him and the battle to save the world from demons. Some of the interpersonal twists are devastating and the lead characters really are incredibly pleasing.
Michael Flynn's "Star" books (Firestar, Lodestar, Roguestar and Falling Stars) are an excellent exploration of the threat of earth crossing asteroids and the future advancement of technology.
Tad Williams' "Memory, Sorrow and Thorn" series, named for three powerful magical swords is another fine fantasy epic. The basic world details will be familiar, but the story is completely different than you might think. The short version of the setup is: "collect the magic swords and save the world", but that hardly does it justice, and the man's ability to twist the reader's preconceptions inside out, sideways and upside down is without parallel. Likewise, his Otherland series, a mixture of virtual reality scifi and bizarre fantasy is wonderfully bizarre and surprising. The ending is especially memorable.
Finally, I'm going to recommend Neal Stephenson's Snow Crash, The Diamond Age and Cryptonomicon. The first two are nominally set in the same world and feature, among other things, katana wielding pizza driver hackers, skateboard messengers, viruses, discussions of Sumeria and the origins of books of the Bible, nanotechnology, massive orgies, powered armor and a chinese revolution. The last is a time frame jumping story about searching for Nazi gold, along with a lot of cryptography, math, at least one secret society and the strangest method of divvying up a dead person's belonging I've ever seen. The only flaw in all of these books is that Stephenson can't write an ending to save his life. The books are brilliant till about 95% through, then he just runs out of words and the story ends. Its always a wild ride up to the end though. All three of these make excellent audiobooks, btw. I've read them and listened to them and there's just something so much better about listening to them. He's got the right style for storytelling (which is different than merely writing).
There's a series whose authors I can't remember and I can't be buggered to look up. The title of one of the books is "By Honor Betray'd". Great bloody scifi/fantasy series about jedi knights and sith lords--er... about two different schools of psuedowizardry fighting it out against an galactic backdrop. the whole things is very Star Wars, but different, and in a lot of ways better. These'd make great movies.