As the crew in WCS knows, I have a bit of an issue with CTDs in recent exes. Since they occur in specific points in a mission, I'm tempted to think it's a problem with the .fs2, but everyone else appears to be able to run the missions with no problem whatsoever...
Cases in hand: My assigned work for WCS and the second mission in Just Another Day (just after a message along the lines of "Can we close the iris now?").
P4 2GHz @ 2133 MHz (I, uh, password-locked the BIOS and forgot the password, so I can't change it.
512 Mb RDRAM (Turbo and some other thing set to their default settings)
ATI Radeon 9700 Pro 128 Mb, Catalyst 4.9 (CTD also in 4.4)
Cordless Logitech iTouch
WinXP Home SP2 (CTD occurred in SP1 as well, for that matter)
SoundBlaster Live! Platinum 5.1
Anything else? Latest drivers all around even where it isn't noted.