I would worry about Windows XP, AMD Duron, and GeForce4. Windows XP isn't compatible with some games. I have heard people with XP can't run Freespace, but some can. GeForce make sure that you have the latest drivers (I assume so because GeForce4 is new.) I personally don't like AMD (Good for overclocking though).
Also make sure that you quit all programs running in the background and/or taskbar items such as anitvirus programs, task manager (disable it), and the internet. After eradicating taskbar programs from memory and Freespace 2 still crashes, hit ALT+CTRL+DEL (Windows 98, not sure for XP) and close all programs except explorer, systray, rundll32, and stimon (Again, not sure for Windows XP)
Try the items listed above. If it still doesn't work, I can't help you.