They're all on a HOTAS, at least in F-16.
Keypads are good when outside of combat and when you're not pulling over 6G trying to evade the enemy fire, or catch them into your sights.
At 6G, your hand would weight a few kilos, so I think it'd be easier just to move your thumb to reach the CM management switch.
Same with locking and firing missiles, I don't know how I would use radar cursor without HOTAS.
And of course, you can lock targets while evading missiles and dropping flares thanks to HOTAS (at least, my setup and real F-16 are capable of this).
On keyboard, you'd need 4 hands (one for CMS keystrokes, one for flight controls, one for cursor controls and one for target management switch).