Been reading "The Hitchhiker's Guide to the Galaxy" lately, have we? =)
That quote in your sig is still one of the best one-liners ever written.

<nitpick> Technically, they already have the resistance, it's just the very few resistant individuals will now outcompete those that aren't resistant. </nitpick>
Apparently, there are certain types of bacteria that don't have much of a natural propensity to develop antibiotic resistance, for whatever reason. I was reading a recent article about scientists being able to sequence the genome of the bubonic plague circa the Black Death (which is pretty crazy in and of itself), and it turns out the thing really wasn't any less resistant to simple antibiotics than the modern incarnation is.