Well so far we haven't had any micrometeorite damage on any interplanetary mission (to my knowledge), so the risk is probably really small in most cases. Though New Horizons' is an interesting exception because we recently discovered that the region around Pluto/Charon is full of debris and even a possible ring system, which poses a significant risk to its current trajectory. Very fortunate that we discovered this well before the encounter so we can change to a safer (though more distant
approach path.)
Probably the best thing we can do with regards to debris is to do our best to avoid it. The Near-Earth environment is probably pretty safe.
I didn't know about this New Horizons probe.
Looking at the wiki real quick...
http://en.wikipedia.org/wiki/New_Horizons"It is expected to be the first spacecraft to fly by and study Pluto and its moons, Charon, Nix, Hydra, S/2011 P 1, and S/2012 P 1"
What the...?! When did Pluto get a bunch of new moons?! I only knew about Charon!

"New Horizons' Long Range Reconnaissance Imager (LORRI) took its first photographs of Jupiter on September 4, 2006."
Ohhhh... Why couldn't they have tacked "Camera" on the end of that? Then we'd have "LORRIC"!
