Also: Those poor hostages.
They got their hazard pay, before they were incinerated. PTMC doesn't have time for condolances!
That runner has a sub-40 run in him. There's lots of little places where he got hung up on level geometry for a moment or had a corner eat half of a charged Fusion volley, where he could potentially pick up a few seconds. The trick is getting a run with solid execution and good luck with the location of key-carriers in Level 20. I find that kind of thing to be an unenviable task, but that's why I watch speed runs, instead of doing them.
There's probably big time gains to be made, if a reliable means of manipulating the AI can be discovered. In the early levels, when you can't just blast the crap out of them in one shot, the bots have a way of planting themselves in the middle of the optimal/only path through an area, chewing up time. If they could be more reliably lured out of position, then there's minutes to be saved.
All that said, excellent routing and execution in that run, on the whole. For a game with lots of levels, few skips, and no ludicrously exploitable bugs (yet), forty minutes is an impressive any% time.