Not really. I have **** for memory, and can handle just about any model you could find. Once it gets in the billions of polys range it ****s out a little more often than otherwise, granted, but that'd only be for FMV work and such, anyway, which only pros need to do.
Can't necessarily vouch for gaming, as I don't play anything particularly technically trying (insert multiple paragraphs of nasty comments about how bad modern games are, I can't be bothered and there's probably an exception I just can't think of... ever, really), but Hegemonia seems to run fine on that front the one time every eon I play it.