I have three hard drives, and this is how I have them partitioned:
Hard Drive 1 (160GB, 7200RPM, 8MB cache, primary master):
C: (System), 7GB
-Windows XP and drivers
D: (Applications), 7GB
-big programs, like Office, Visual Studio, Paint Shop Pro, etc.
E: (Utilities), 1GB
-small programs, like WinZip, WinRAR, eMule, etc.
F: (Games), 145GB
Hard Drive 2 (160GB, 7200RPM, 8MB cache, primary slave):
G: (Downloads), 155GB
-recently downloaded stuff, along with program installation files (I install Office, etc. straight off my hard drive), patches, game maps, etc.
H: (Documents), 4GB
-contains 'My Documents' and 'Favorites' directories (I used TweakUI to redirect Windows to them)
Hard Drive 3 (120GB, 7200RPM, 2MB cache, RAID IDE):
I: (Temp), 120GB
-miscellaneous crap that I don't want cluttering up my 'Downloads' partition
I'm considering buying another hard drive since I'm down to less than a hundred gigs free, a 300GB one (SATA, 7200RPM, 16MB cache), which I've seen on sale for Can$340, but it'll screw up my partitions if I do. Do you know if it's possible to have one partition span multiple drives? That way I could have the 300GB be the 'Games' drive while I'd combine the two 160GB disks to form 'Downloads'.