Well, I would think that capital ship missiles would be fairly obsolete in the Freespace universe (looking forward to it in the Saga mod though). Any warhead would be shot down -long- before impact.
We're talking about two different systems, though. David Weber's battles are all in Einsteinian physics. The battles are usually fought at sub-light speeds, but at very fast sub-light speeds. We're talking significant fractions of lightspeed. Also, capships in the Honorverse travel in enormous task forces, so we're rarely talking about one solitary Super Dreadnought here. Additionally, missiles are not fired one at a time, but in salvos, from numerous missile batteries. So one Super Dreadnought would fire hundreds of missiles simultaneously. Most of these would still be shot down or evaded using advanced Electronic Warfare techniques we don't see in the game. However any that get through are devastating.
The typical missile contained a nuclear warhead that when exploded, directed its energy to one end of the warhead and concentrated the energy into a laser beam. Depending on the type of explosion, more specifically the energy released, the laser could be an X-ray laser, or an even more devastating Gamma Ray laser, or graser. Rarely, the missiles are actually plain nuclear warheads. What powers all vessels in the honorverse is an impeller which forms a gravemetric plane above and below the vessel, this includes missiles. These planes are impervious to all weapons, but they can be closed by sidewalls which are like shields. These sidewalls can lessen the damage of the lasers but are still devastating nonetheless. There are no impact missiles in the Honorverse.
Missiles are used because battles between fleets take place several light minutes distant from eachother. So conventional weapons are useless at that range. Once fleets become several light seconds distant they actually use regular broadside mounted beam weapons such as X-ray lasers and Grasers. Ship-to-ship battles of this sort are devastating.
In the Honoverse, there are small craft called Light Attack Craft or LACs that function as fighters, bombers, and interceptors. Typical battles in the Honorverse are too large for Fred to handle, dealing with thousands of LAC's, hundreds of small warships, and several dozen large warships, such as the Superdreadnoughts. In addition the physics would have to be redesigned. This is a plausible space strategy game, but I can't see it in the FS universe.