I started using a .23 kernel and this went away. So I'm gussing this was related to ALSA.
In my case its much worse on .23. I have the same only when using hw:0,0.
Cant use default or any other higher level (like surround*) cause I get much more statics then before.
And again its only on fs2_open.
EDIT: ok, not only. So it seems that in contradiction they broke alsa in .23 for me. But still on hw:0,0 (where it behaves properly) I still have the issue described above.
BTW: ni1s what is your soundcard (what alsa driver you use)?
EDIT2: Upgrading alsa-lib to 1.0.15 along with kernel somewhat helped. I can use my custom 'default' device again and its not worse then it was on .22. Though the main issue described in this thread is still present :-(