My advice as always is to avoid truespace and it's abysmal modelling and UVing toolset alltogether at all costs, and focus on one of the others. I use blender because it's free, enormously powerful and rapidly evolving, but you can do just as well with 3ds max, maya, cinema 4d or anything else that can export collada DAE files.
Not counting TS for aforementioned reasons, currently blender is still the easiest platform to build, UV, texture, set up and convert to POF from. It does indeed have a confusing to look at interface, but you'll soon realise you barely use that interface and just use easy to learn keyboard shortcuts for almost everything - which is a million times faster than the push-button approach of TS.
