Even though I got my copy of FS1 from GOG, it still runs fine on my computer. My computer happens to run on Vista. It did take a while to get it (FS1) working, though.
Check the status of the application with your AV/Firewall. That needs to be in the green first. Next, go to compatibility options. If Vista can do one thing, it can be quite flexible with program compatibility. Right-click for the properties option on the app and apply the appropriate settings. Try a few things... it should work eventually. AND, if it does not, I'll look into my own settings and find preciesly what is making the app tick on my computer. Good luck!
-Thaeris