hell. yes.
the controls might be a little weird though. i'm guessing the nunchuck for front/side movement, remote will work as a virtual joystick of sorts. but up and down?
My preferences for movement:
Joystick - Up, Left, Right, Down
Nunchuck* buttons - Forward & Backward
Wiimote "motion controller" - Turning
No one will do it that way, though. And if Metroid Prime 3 is any clue, FPS games don't work very well with the system (see: 'STOP LOOKING AT THE CEILING', as well as 'LOOK AT THE CEILING, DAMN YOU'). :/
*(Why do I picture Norris in a Nunnery outfit?)