There are several things that seem to disprove the hypothesis of universe being deterministic. Mainly, Bell inequality experiments related to hidden variables (or lack thereof) in quantum physics. Which, for me at least, is a preferable reality to completely discrete and deterministic universe, since I despise destiny and fart in the general direction of fate.
This, of course, does not have any bearing on the meaning of life, universe and everything. My opinion is that such things are part of person, and not applicable to other people or entities in the universe. So, if universe has a personality, then it may or may not have a "meaning". If it doesn't have a personality, then it doesn't have meaning aside from what sentient beings living in it consider it to be.
Maybe the purpose of universe is, or was, or will be to produce
YOU... or to be more precise, you wouldn't be here to observe the universe if the universe didn't exist in a manner that allowed the evolution of observers.
