Well, the most effective missile in the game, for me, was the Beluga, you could take out most of a squad by simply sitting outside aggro range and firing them off at the targets

In X's defence, it needs to be remembered that the game did try to control, quite literally, thousands of ships in hundreds of sectors all at the same time, and anything going on OOS was done on a grid (from the looks of things) and used 'dice roll' mechanics in order to facilitate that. The problem was that this led to really weird combat situations where I would lose ships in battles that should have been incredibly in their favour.
As much as I am loathe to think of the responses this will generate, in some ways X reminds me of some of Derek Smarts work, a brilliant idea that is held back by both hardware and UI limitations. When I had X3 running on my old computer it used to get
really jerky as the game matured, my i7 handles it a lot better, but these really are games that are designed to by played on computers more powerful than the current average, so I'm hoping that Rebirth will follow that same trend.