If the drive is SATA, then yes. If the drive is PATA (40+ pins) then no.
Caveat: You
can use a PATA laptop drive in a desktop,
if you buy an adapter (it should come with the adapter for the pins + a power adapter to take 5V from a molex power plug and put it in the appropriate place in the laptop pins) Like this one
here (Newegg, ~$15 US after shipping).
EDIT: And, about the whole CCleaner / registry deal, I believe that some bad "registry cleaners" go too far to seem like a good program... the more "errors" they find, the better they seem. Like a anti-spyware program calling a
cookie a "medium"-classed threat to your system. Then, when the user goes ahead and removes the "problems", it causes issues like the ones The_E and CaptJosh are talking about. I do believe CCleaner doesn't find the "errors" that other programs do, as
it knows better than to change most settings that might cause instability. See?
Just because Uniblue Registry Cleaner (to pick a random one) crashed a system doesn't make all registry cleaners bad.
I use the registry cleaners on both IOBit Advanced SystemCare Free and CCleaner on
every computer I clean, and do you know how many bad results I've had?
None. (I'm not saying that it's necessarily a good idea for
anyone to do what I'm doing, but anyone who knows how to use System Restore / the built-in undo function in IOBit ASC Free should be able to manage just fine
if anything did happen.)
Although, yeah, the exclusions above kinda limit the users that should be able to use registry cleaners. I just don't get how The E is saying he always has to fix CCleaner's problems when I've never seen
one... I'm pretty sure what you're running into is crapware released by companies that are just after the customers' wallets, whatever happens after they get your info, they could care the f--- less.