And 100 years ago we had no way at all to build a vessel to get a group of monkeys to the moon safety. Your pessimism is uncharacteristic and (while injecting some measure of realism into the discussion) ultimately non-constructive. Hardly like your normal posts at all.
Okay, let's see. Let us assume that we find a habitable planet (habitable in this case being defined as a planet within the habitable zone of a stable star, with a confirmed nitrogen-oxygen atmosphere, and a surface gravity around that of Earth) in a system 100 light years away.
Let us further assume that
c remains as the absolute speed limit, and that the laws of thermodynamics will remain valid.
Finally, we will assume a willingness to launch a colonization effort on behalf of humanity.
Here are the challenges we need to overcome:
1. Build a vessel sturdy and fast enough to get to our target.
2. This vessel needs to carry a crew complement large enough to give birth to a new variant of human civilization.
3. The crew needs to have a sampling of skills available to cover all eventualities.
4. The vessel needs to be able to essentially provide all the technological capabilities humanity possesses at that point, an agricultural/industrial complex in a box, if you will.
5. The vessel needs to be capable of ensuring the survival of the entire colony seed while in transit.
Let us tackle these points in random order. Starting off with 2 and 3, what would be an appropriate size for our colony seed? Personally, I believe we would be looking at a population figure north of several hundred thousand people. Why? Because, in order to be as disaster-proof as we can make this whole thing, we need to have enough people on board with a diverse enough skillset to, if needed, bootstrap the colony to a tech level where it can flourish on this new world without the toys we brought with us on our vessel. Note that it isn't enough to send along people who can operate the machinery, we want people who can design these things. Then we need people who can teach these skills to others. And people who can run the societal support structure all of the above implies.
Now, we need to look at number 4. Our vessel needs to be equipped with enough tools to do any form of terraforming our newfound planet may require, including having a feedstock of pioneer species to, if necessary, bootstrap a compatible biosphere from scratch. This necessitates advances in biology (especially gene manipulation and cloning) we do not have at the moment. The problem here is that we cannot be certain that there's going to be anything usable at the other end of our trip, so we best pack everything we can to make our new home usable for our purposes.
On to point 5. Obviously, this whole endeavour is pointless if there's a risk that a percentage of our colonists dies en route. Given that we're looking at a transit time of several hundred years, there are two possible approaches. Cryogenic sleep or a generation ship. The first one is as of now an unknown quantity. We do not know how, or even if, we can freeze a human being for a long period of time and wake him or her up again. However, given the other constraints, this is likely to be the most attractive option.
Generation ships run into a different set of problems. One, they require full self-sufficiency in order to feed all our canned monkeys. Two, the society needs to be set up in a way that guarantees that we do not lose essential skills in transit. Three, the society needs to be kept from blowing itself up over some stupid squabble. Four, this society needs to be able to make the transition from shipboard life to planet colonization. All of these require a degree of social engineering we do not have available at the moment.
Now, all of the above has implications on point 1. We need a vessel capable of transporting all of the above, fast enough, and safe enough to do some useful things at the other end. There are a lot of numbers involved here that are appropriately astronomical.
So yes. I am heavily skeptical of extrasolar colonization efforts. Barring the discovery of several magic wands to sidestep these issues, I am firmly convinced that we are not going to see the launch of such an effort in our lifetime. That does not mean it is impossible; just highly unlikely.