Wtf is wrong with you guys? It's a serious question, give serious answers.
headdie gets a virtual cookie for being on-topic
It's an interesting question actually... regardless of who the President is, if there was nobody on the Supreme Court, could the senate downvote or filibuster every nomination the President makes? If they did, what could be done about it?
Actually the same question sorta goes for when there's any number of vacancies on the Supreme Court, or any President-appointed position for that matter.
E.g. supposing the head of some department was a position appointed by the President, could the Senate effectively kill that department by refusing to approve any nominee? ("refusing" including the filibuster in this case)