While yes, NoScript can be frustrating to set up, you can't get something for nothing.
Some people may not want to be bothered with having to be aware of their own surfing habits or paying attention to what links to where they go. Myself, I can't imagine NOT being as aware of that as I can be.
And while AdBlockPlus is useful (I use it in conjunction with NoScript), it still has to rely on subscriptions outside of a users control. And you would have no idea if a subscription got compromised on you until you got hit with it. Which still leads into the whole user awareness bit. Or you have to start filling in either a whitelist or blacklist yourself, which can be time consuming.
I'd rather have a site only partial load and look funky until I examine the NoScript blocked elements than be surprised by random application or desktop popup "X" suddenly showing up on my machine.
I should also point out, I can only converse on the two above as they relate to FireFox. I don't use Chrome for anything but NetFlix and Hulu and even then, I use the Iron Browser variant.