Probably the easiest way of getting it to work would be to do the install to your C drive, apply the no CD patch, then
move the Tachyon folder to the F drive and just run the space.exe from there, or you can make a shortcut to space.exe.
Since you already have it installed to F, you could probably use the no-cd patch against that, just remember to change the
directory it is installing the patch to, to the F folder where you have Tach installed.
Hypothetically, that should work. Using vanilla tachyon it won't work because the game will seek out the install folder (C:\program files\novalogic\tachyon)
and when it doesn't find it, it'll fail out. It's too old to be smart enough to look in the other directory folder.