Why would you set a campaign there?
If you want to do something set during FS1 or before it it's probably going to be in the vicinity of Sol and Vasuda.
If you want to do something set in FS2 you have to do it in a system where the action is.
If you want to go back to Sol you have to do Delta Serpentis.
If you want to do a new Shivan incursion, Ross 128 is the obvious one, or one of the systems adjoining Capella. You could do them coming from somewhere else completely, but if they're systems out in the boonies there's an obvious contingency - load a destroyer up with Meson Bombs and cut them off.
Even if you want to do something with the Ancients, you're looking at Altair.
That's not to say you couldn't do a good story there, there's just not much pull over the core systems.
Maybe you could do a wild west type story, the uncivilised frontier. I don't remember where Sync and Homesick were set at the outset, but it could have been those systems. I think Transcend starts out there and then you traverse half a dozen systems.
Derelict's at the other end of the map, but it's got a similar feel of being in the backwaters.
There was one I played forever ago where you were at the other end of the map and they were sealing off jump nodes to uncharted space just in case as part of a post-Capella clean up. Shivans did end up making an appearance. I can't for the life of me remember the name of it, though.