Well, if you're amused by M*A*S*H-meets-Dilbert style humor as applied to first-person-shooters, then you'll probably like it.
RvB: The Blood Gulch Chronicles is a work of "machinima" (gag), short films created with videogame characters as "actors". The entire series is set in Halo's Blood Gulch CTF map. One of the running gags is how utterly pointless it is for the red and blue armies to both have bases in this useless sealed-off box canyon. There are a few Halo-specific jokes (like how the Warthog's machine gun never runs out of ammo), but for the most part it's pretty non-specific.
The characters are hilarious, and the voice acting is better than a lot of so-called professional work I've heard.