There is still potential for Trek as a liscense, but they need to break the self-imposed limits and also make something with a clear storyline.
Say a 100 episode series where a more or less independent city-like starship (like the Ent D was supposed to be...) with all of the bells and whistles we see in the Trek universe (slipstream, ablative armor, transphasic torps, you name it) winds up doing inter-galactic travel and is involved in some large scale conflicts that could threaten even the Milky Way despite the great barrier. (The Kelvan Empire perhaps?)
The aliens should be alien, mostly CGI, and each faction/civilization has their own unique tech basis and look different from normal Trek.
...and the ship is able to return to the Federation to avoid Voyager/Atlantis syndrome.