Actually what would make Trek work are two things:
Go back to the initial 'Next Gen' idea of "no technobabble because we're too high tech for it" (i.e. no dilithium crystals breaking down every episode).
Have a large ship that's almost like a city which is self-sufficient but has all of the bells and whistles of all previous Trek serieses. (slipstream, phased cloaks, you name it)
Have this ship as part of the Federation's new voyages of exploration though the galaxy and add in a curveball:
Another civilization has made contact with the Milky Way, and this ship goes through their foothold on a mission of exploration.
A culture that is very technologically advanced, consists of millions of species and dozens of galaxies but one major issue: highly individualistic and hedonistic- they interfere with everything.
Both the feds and this group are well-intentioned but most episodes deal with the culture clash. While this new ship goes around discovering and contacting new species, it's also dealing with the reprecussions of this other culture. (and they reprimand the Federation for not intervening in genocidal wars, etc. on less advanced planets)
Pretty much the metaplot would look at colonialization v.s. non-interference and the reprecussions of both. Tons of tech for geek mastrubation, but also it's a sideline to the reprecussions of such tech. (sure you have that particle of the week, but you blew up half a star system MacKay...)
The Federation meddling in these people's galaxy, and their meddling in the regular 'Trek one is another big issue. What happens when these people meet the Borg and feel that experiencing being a drone is a good idea? Sure they leave the Collective, but now the Borg have assimilated some of that tech and use it on a rampage.
What are the side effects of these people encountering the Kelvan Empire and a few decide to conquer some planets for them and also mention what happened to their scouting party?
What about the V'Ger machine planet?
etc. etc.
Pretty much establish a few new species as main players, but mainly look at dropped plot threads that deal with the inter-galactic politics.