Well, several bombers with a couple of fighters for escort would be perfectly capable of taking out a destroyer, while:
a) being possibly cheaper than a badass cruiser like a Lilith
b) having possibly less crew = less casualties
c) it's harder for big ships to take out several smaller targets than one big
Hmmm, Mars' post got me wonder... As we know, most of the FS ships are covered with lots of armour, essentially eliminating most soft spots. If you look at an Orion, the only reasonable place that could serve to one-hit-cripple it would be the hangar. Fly into it and fire off a Helios - KABOOM. Besides, I started thinking - what would happen if a beam emitter was destroyed while, well, "loading up" before the shot ? In game, we know that nuffin really happens, but one could expect that the huge amounts of power cumulating just before the shot would be kind of unstable. If a lucky shot would destroy the turret in this exact moment, shouldn't this energy just release, effectively unleashing the most of the power of the beam on the ship's hull ?
Although it wouldn't do much bad to a Sathanas, because its beams are on the spines, but I believe that for example a Lilith should loose most of it's hull in the subsequent explosion. If that was the case, then Lilith would be a really dangerous ship not only to the enemy, but also to itself.