How serious are we talking? If the answer is "fairly", I would suggest looking at this:
The MIT-authored "Mars One Feasibility Study" (.pdf)
I don't feel like going into detail (that's what the study is for), but I can summarize what I feel are the most salient points, plus my own musings:
a) Resupply / rescue are Things That Will Not Happen. A "simple" Luna colony would need to hold out for several days in an emergency situation, assuming a relief mission were immediately ready to launch. A trip to Mars involves approximately a year of transit once the planetary transfer windows are aligned, which itself doesn't happen instantly. I personally mostly rule out re-supply missions because past a certain number of flights, the sheer mass of spare parts you're sending will equal the mass of new equipment.
ergo,
b) Pretty much everything needed for survival would eventually need to come from Mars' resources; alternatively- "they're on their own".
However on paper, Mars offers all the resources needed for human survival and permanent colonization.
*The atmosphere, though thin, contains carbon dioxide gas. This can be processed into liquid hydrocarbons (gasoline, polymer feedstocks) through the
Fischer-Tropsch Process, which also produces water, albeit at significant energy cost.
I'll get into technology barriers in a bit.*Water ice exists as soil permafrost and as polar ice caps. Electrolysis results in oxygen and hydrogen, which has several potential uses (fuel cells, fusion reactor, chemical feedstock...).
*Martian soil is red due to presence of iron oxide. Barring the discovery of convenient ore seams, it should theoretically be possible to refine and smelt martian soil for iron metal.
*No idea if Martian soil is good for growing crops, but hydroponic techniques don't care.
taking this onboard,
c) We can conceptualize the technologies that would be required to exploit these resources and put down permanent roots.
*Electrical energy is an absolute must. Solar power is still an option, but will be less effective owing to Mars' greater distance from the sun. Preferable solutions include miniaturized fission reactors, fuel-cell systems, or possibly a fusion device. The more power we can bring, the better- we'll need a lot of juice to refine resources.
*Small-scale and rugged extraction and refining systems need to be developed. In "the biz", these devices are known as In-Situ Resource Utilization systems (ISRU). Some basic engineering has been done in this technology branch, but it is nowhere near ready for deployment.
*Finally, we need a solution to actually convert refined materials into usable widgets. 3d-printing systems show a lot of promise, but we still need highly rugged devices that are capable of working with multiple materials, including metal, AND subordinate gadgets that can still work with cruder engineering tolerances- we simply won't be doing precision work with low-quality metal half an AU from earth, and our whole engineering system needs to account for this.
I'm not addressing the economic costs because it would be self-evidently colossal.
In general, my take is that the initial establishment would be the hardest part. Once resource deposits are located, unexpected hazards surmounted, and LOCAL re-supply systems in place, it becomes a lot easier to move forward. Oh and things that would be easier? Well the reduced gravity would throw some curveballs into general engineering and construction, which could go either way, but human adaptation/development in permanent low-gravity is a complete X factor right now.
Frankly, we aren't ready to settle on Mars yet. I can envision what we'd need, and a day when we can go for it, but this is not the time. If I were the God-Director of the Human Space Program, I'd pull back on these dreams of Mars colonies. Sure, I could endorse a temporary visit, but we really should be shaking down our extraterrestrial colonization systems on the Moon.
Ed: huehue I didn't actually read the thread and some of these things have been addressed already. Ah well, I collected it all more effectively.
