Not to mention that these launchers with these bigger tiles are used to launch full games, not merely mods. I think the tile size in Knossos handily show the difference
Also, I think we should mention that increasing the size of these tiles would make scrolling through Explore tab a bit more tedious... Look at how many mods are there already, if I expand the Knossos window to full screen, there are about 3 and a half full "pages" of stuff in there (1920x1080). I think bigger tiles would just be not useful.
However, if you really want to have some alternative to the current GUI, I think I've got a couple rather simple ideas:
1. The tiles are displayed without the title underneath. When hovering the cursor over a tile, the title shows up like the rest of the interface over the tile, above Play/Details buttons.
2. Same as 1. but when hovering the cursor over a tile, the mod title "slides out" downward (or upward if you think it'll be better) from underneath the tile to be displayed.
3. Just make a selectable alternative mod list display mode in Knossos - just a simple list! For example, a single line of the list:
[Mod title] --- [Play/Update/Install] - [Details] - [V] ---------------------- [Installed!/Update avail!]
[V] being the dropdown menu currently found in the normal tile view.
Play/Update/Install, Details and the dropdown menu buttons being hidden until you hover your cursor above the entry.
I think it's possible to reuse every piece of the GUI artwork here too.