No, because we're getting back into the gigaton =/= massive destruction in space issue. And AM containment won't get much better than a strict containment field that, even if Star-Trek like in its strength (and we're talking about something not feasable in the FS universe) it would still be relatively large compared to the amount of antimatter that it would contain. Remember that if it comes in to contact with any matter, it goes boom. And that includes the containment unit.
The other issue is that the radiation released by matter/antimatter reaction isn't necessarily of the form that's going to incur massive damage on armor plating. As I recall, it's mostly high-energy radiation in the form of X-rays and gamma rays, neither of which will have a huge impact on the hull itself. On the crews inside, however, the effects would be pretty substantial if the radiation shielding wasn't adequate.