Well, the first two days it came out I played it for about 30 hours in total, as I had them off work coincidentally, and I was ill this week and put another ~30-40 hours in, while playing it whenever I got the chance otherwise.
Overall the games pretty good, I spent a while just exploring, bumped into a bunch of dragon priests almost straight away, between them and the archmage robes which I got very early on as well, I never bothered with smithing or enchanting really.
Most of my 'wasted' time was spent on inventory management (sigh, fecking hate), though at level 39 my character has something like ~120k gold and two fully furnished properties and it wasn't farmed/ground/craftwhored.
The most enjoyable part was probably hunting dragon priests and words of power - faction quests (stormcloak) and the destruction skill quest. While trying to avoid plot spoiling, I quite liked the daedric quests too because of how they tended to trick you into doing things (though some were blatant and less amusing).
If you are going to do some hardcore crafting I suggest you do the star of azula quest early as well, it's so useful for enchanting.
Things that annoyed me;
Vendors never having enough gold to buy certain items without the speech perk.
Despite not carrying around much in excess, constantly needing to return to white run to put stuff in my house or sell it, mostly because of potions ...
The end.
The way that almost everyone is a bad guy, pretty much regardless of what paths you choose.
A fair few of the assassins guild quests (though this may be because I'm relatively impatient and therefore probably suck as an assassin).
The fact that certain 'quest' items can never, ever, be removed from your inventory (
As soon as you pick up the elder scroll, it's stuck in your inventory forever, same for some of the bard quest items (EVEN after you had them in!) and some other stuff
)
Blackreach (despite being pretty and kinda cool for the first 10 minutes, it quickly becomes an annoying area you can't use a map on or fast travel around).
Companions (they really are more of a nuisance to me when I notice them, when they're not around I feel somewhat overwhelmed with enemies at times too).
Being oneshot (as a mage some better mage armour would be nice, by the end of the game pretty much anything killed me immediately if it ever actually managed to get in melee with me, which I'll admit didn't happen much but was annoying when it did, happened occasionally via arrows as well).
Brawling becomes very VERY boring late game.
Did I mention the fact that pots weigh way too much?
The crappiness of the alchemy system.
Dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dragons dovah, dovah, dov, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons, dragons. - annoying to read? good, this is how many times I had to fight them, not including the world eater, it gets boring.
Pretty comparable to FO3.
Oh and I loved the 'power' reward from the assassins guild, though that may be because I didn't overuse him, cuz I can quickly see the novelty of his sound bytes becoming annoying.
I quite liked the mage guild quests too.