Mongoose, so understanding say.... physics drives you insane?
After all, it's the foundation of reality in which the human condition rests.
Amusingly enough, the more we've learned about the modern branches of physics, the more we've come to realize that what we call "understanding" can only go so far. I think Feynman said it best: "Anyone who says that they understand Quantum Mechanics does not understand Quantum Mechanics."

But to answer your question, no, studying basic physical laws doesn't make me uncomfortable in the least, because I consider them much more in the realm of abstractions. But being in a situation where you're always self-analyzing your every action, thinking to yourself, "Oh hey, I felt like donating money to that charity because behavioral evolution has conditioned me to perform social group altruism"? Yeah, pretty sure that'd drive me off the deep end.
Just curious- why is that? After reading the last few pages (late to the party, I know), 'tutta is simply explaining our thoughts (needs and desires) based on biology and environmental conditioning. Our thoughts, and the wants and desires that the last page has been discussing, have a basis in our brain chemistry which is directly molded by our biology. I would much prefer these processes to be understood- and therefore predictable- than unknown and uncertain.
Quite simply, it's because, unlike Ryan and Battuta, I'm of the firm belief that we are each more than a simple product of our physical biology. I believe that there is an intangibility to us, something that can't be explained away by performing a complete neural mapping and analysis of active brain chemistry. And in that context, for my own satisfaction in what I consider to be the purpose of my own life, I'd rather not delve down those paths myself.