Derelict doesn't actually 'work' with the 3.6.12 MVPs; there's a mission in there that's b0rked by beam fade. I hit it a while back. That mission with the cruisers and the beam cannon.
and Infamus, the only problems with running mods on SCP/MVPs would be:
* running a mod that requires newer mediavps on older mediavps.
* running
some older mods on the 3.6.12 MediaVPs which break some aspects of compatibility, like the aforementioned beam fade.
If you aren't sure about some aspect of the engine (and from your posting history, this happens a lot) feel free to ask.
Although, if you were replying to Deadly In A Shadow's post, he wasn't talking about compatibility at all- he was making a comment about the increasing use of HTL models and resource-intensive graphics.
I've gotten Derelict to work with both MediaVPs 3.6.12 and SCP 3.6.12 Inferno AT THE SAME TIME.
FS works well with the 3.6.12 MVPs and 3.6.12 FSO because they were pretty much designed to work together. The identical version number should have tipped you off. The newer FSO builds (such as 3.6.12, compared to 3.6.10) don't add much load at all compared to what the CPU goes through trying to render the MediaVPs, so running them AT THE SAME TIME is not really special at all.
And then there's Antipodes 6, which is just awesome.